Thrombocytopenia is commonly encountered hematological abnormality, which might be attributed to hepatitis C virus (HCV) in acute and chronic infection. This study aims to determine the prevalence of thrombocytopenia as a clinical manifestation of chronic HCV infection in non-cirrhotic patients having spleen of normal size. A cross sectional study was carried out in Ayub Teaching Hospital, Abbottabad, Khyber Pakhtunkhwa, Pakistan in Gastroenterology and Medical Outpatient Department from January to October 2017. The investigation was carried out on patients between age 20 to 60 years with anti-HCV antibody positive. All patients having liver cirrhosis, or fibrosis and splenomegaly, or having thrombocytopenia from other causes i.e. any drug use or other chronic infections were excluded from the study. A total of 67 patients fulfilling the criteria were selected. Thrombocytopenia was observed in 34.3% of the subjects, among them 17.9% exhibited mild thrombocytopenia (150000/μL to 400000/μL); 11.9% (51000/μL to 100000/μL) exhibited moderate thrombocytopenia while 4.5% (less than 50000/μL) showed severe thrombocytopenia. Thus, the study exhibited the presence of thrombocytopenia in chronic HCV patients without liver cirrhosis and splenomegaly that proves the contribution of HCV to induce thrombocytopenia.
Keywords:Thrombocytopenia, HCV, Cirrhosis