A J Life Sci. 2018, 1 (2): 77-81

Occurrence of Thrombocytopenia in Non-Cirrhotic Hepatitis C Positive Patients

Muhammad Ayyaz 1, Syed Muhamamd Hassan 1, Muzna Hashmi2,  Muhammad Tahir Khan3,Anwar Sheed Khan4, Shabir Ahmad5, Aamir Aziz5,  Wasim sajjad6, Muhammad Irfan5

1Department of Gastroenterology, Ayub Teaching Hospital, Abbottabad, Pakistan

2Department of Microbiology, Quaid-i-Azam University, Islamabad, Pakistan

3Capital University of Science & Technology, Islamabad, Pakistan

4Khyber Medical University Peshawar, Peshawar, Pakistan

5Institute of Biological Sciences, Sarhad University of Science and Information Technology, Peshawar, Pakistan

6Key laboratory of petroleum resources, Gansu province/Key laboratory of petroleum resources research, Institute of Geology and Geophysics, CAS, Lanzhou 730000, P.R. China.



Abstract

Thrombocytopenia is commonly encountered hematological abnormality, which might be attributed to hepatitis C virus (HCV) in acute and chronic infection. This study aims to determine the prevalence of thrombocytopenia as a clinical manifestation of chronic HCV infection in non-cirrhotic patients having spleen of normal size. A cross sectional study was carried out in Ayub Teaching Hospital, Abbottabad, Khyber Pakhtunkhwa, Pakistan in Gastroenterology and Medical Outpatient Department from January to October 2017. The investigation was carried out on patients between age 20 to 60 years with anti-HCV antibody positive. All patients having liver cirrhosis, or fibrosis and splenomegaly, or having thrombocytopenia from other causes i.e. any drug use or other chronic infections were excluded from the study. A total of 67 patients fulfilling the criteria were selected. Thrombocytopenia was observed in 34.3% of the subjects, among them 17.9% exhibited mild thrombocytopenia (150000/μL to 400000/μL); 11.9% (51000/μL to 100000/μL) exhibited moderate thrombocytopenia while 4.5% (less than 50000/μL) showed severe thrombocytopenia. Thus, the study exhibited the presence of thrombocytopenia in chronic HCV patients without liver cirrhosis and splenomegaly that proves the contribution of HCV to induce thrombocytopenia.

 

Keywords:Thrombocytopenia, HCV, Cirrhosis

Received

Received Revised

Accepted

Available Online


Corresponding author email:

irfanmuhammad299@gmail.com

How to Cite

Ayyaz M, Hassan M, Hashmi M, Khan MT, Khan AS, Hassan S, Sajjad W, Irfan M. Occurrence of Thrombocytopenia in Non-Cirrhotic Hepatitis C Positive Patients. Abasyn Journal of Life Sciences 2018; 1(2): 77-81