AJ Life Sci. 2020, 3 (2): 175-183

The Role of Mitochondria in Alzheimer's Disease and its Potential Therapies

Syed Shahab Ud Din Shah *, Shah Hussain

Department of Biochemistry, Quaid-i-Azam University Islamabad, Pakistan



Abstract

Alzheimer's disease (AD) is a common form of dementia, affecting millions of people worldwide, mostly the elderly population. The gradual decline in cognitive functions, loss of memory, and sleep disorder are the most frequently reported in AD patients. Multiple studies have been carried out to find a potential therapeutic approach to prevent the progression of Alzheimer's disease and increase the performance of cognitive abilities. Mitochondrialdysfunction leading to oxidative stress and other environmental factors, diet and lifestyle are the major risk factors. Mitochondria playan essential role and are a potential therapeutic target for treating and preventing AD progression. Various biochemical molecules involved in mitochondrial metabolic pathways are tested as directly acting on mitochondria. Numerous antioxidants are considered as a potential treatment for AD. Here, we highlighted the emerging mitochondrial base therapies and potent antioxidants that can beused in Alzheimer's disease treatments.

Keywords: Alzheimer's Disease, Mitochondria, Therapies, Antioxidants

Received

October 29, 2020

Received Revised

December 29, 2020

Accepted

December 29, 2020

Available Online

December 31, 2020


Corresponding author email:

Syed.shahab33@gmail.com

How to Cite

Shah SSUD, Hussain S. The Role of Mitochondria in Alzheimer's Disease and its Potential Therapies. Abasyn Journal of Life Sciences 2020; 3(2): 175- 183.

Abasyn Journal of Life Sciences , ISSN (online): 2663-1040, Published by Abasyn University