AJ Life Sci. 2020, 3 (2): 111-128

Treatment of Acute Myeloid Leukemia:A Concise Overview

Mudassir Khan 1, Zerbab Naeem , Kainaat Mumtaz 1, Zahra Sajid 1, Dilawar Khan 1 , FaizanUllah 2, Esraa Ghazy 3, Tahir Omer 4

1 Department of Healthcare Biotechnology, Atta-Ur-Rahman School of Applied Biosciences (ASAB), National University of Science and Technology (NUST), Islamabad, Pakistan.
2 Department of Genetics, Hazara University Mansehra, Khyber Pakhtunkhwa, Pakistan
3 Department of Pharmacy, Al-Rasheed University College, Baghdad-Iraq
4 Department of Life Sciences and Education, University of South Wales, Cardiff -United Kingdom



Abstract

Acute myeloid leukemia (AML) is a disease characterized byhematopoietic and progenitor stem cells disorder, resulting in theirproliferation and accumulation in bone marrow which leads tohematopoietic failure. It is an aggressive form of cancer that typicallydemands quick decision-making. In case of AML, the addition of drugefflux inhibitors to the chemotherapeutic regimen may improve outcomesin patients. With the advancement in treatment strategies, patients cannow receive chemotherapy, radiation therapy or additional stem celltransplants. Specific genetic mutations in leukemic cells provide thedirection for treatment and determine the overall survival rate ofpatients. Older patients have adverse treatment consequences as age isan important factor in AML prognosis. We critically reviewed multipleexisting therapies for AML. Optimization of traditional therapies remainmajor concern of scientists. However, little bit advancement has beenmade in current years. There is immense need of novel and targetedtherapies to treat AML and reduce its relapse chances.

Keywords: AML, Leukemia, Treatment

Received

October 10, 2020

Received Revised

November 5, 2020

Accepted

November 7, 2020

Available Online

December 31, 2020


Corresponding author email:

dilawar_qau@yahoo.com

How to Cite

Khan M, Naeem Z, Mumtaz K, Sajid Z, Khan D, Ullah F, Ghazy E, Omer T. Psyllium Husk as a natural remedy against several diseases- A mini review. Abasyn Journal of Life Sciences 2020; 3(2): 111-128.

Abasyn Journal of Life Sciences , ISSN (online): 2663-1040, Published by Abasyn University