AJ Life Sci. 2020, 3 (2): 1-9

Insights into Acute Myeloid Leukemia: Critical Analysis on its Wide Aspects

Mudassir Khan 1, Misbahud Din 2, Zerbab Naeem , Zahra Sajid :, Dilawar Khan :, Muhammad Dawood Amjad :, Aurang Zeb :, Faheem Anwar , Mehran Akhtar , Sana Noreen

1 Department of Healthcare Biotechnology, Atta-Ur-Rahman School of Applied Biosciences (ASAB), NationalUniversity of Science and Technology (NUST), Islamabad, Pakistan
2 Department of Biotechnology, Quaid-i-Azam University Islamabad, Pakistan
3 School of Biology and Basic Medical Sciences Soochow University, Suzhou, China
4 Department of Genetics, Hazara University, Mansehra, Pakistan
5 Department of Biotechnology, COMSATS University Islamabad, Abbottabad Campus, Pakistan
6 University Institute of Diet and Nutritional Sciences, The University of Lahore, Pakistan



Abstract

Acute myeloid leukaemia (AML) is a heterogeneous, most common type ofacute leukaemia that involves mutation in haematopoietic and progenitorsstem cells (HPSCs) leading to uncontrolled division, self-renewal anddifferentiation. Though it was untreatable about a half century ago, AML isnow considered to be treatable in up to 40% of adults and those who are ator under 60 years of age. For the post-induction treatment, the mutationtesting and cytogenetics are still an important prognostic tool. The AMLtreatment remains unchanged for almost three decades, although the fieldis advanced with the discovery of new drugs and deep understanding of thedisease biology. Still, many people are relapsing and are dying eventuallyfrom the disease. This review discusses the broader aspects of AML,reflecting some of the most important and productive areas of research onthe subject and was conducted using thoroughly searching databases,including Health Research and Development Information network Plus(HERDIN Plus), google scholar and PubMed to critically analysesthe recentadvances, available treatments and future prospectives of AML.

Keywords: AML; Pathogenesis; Treatment; Relapse

Received

August 12, 2020

Received Revised

September 21, 2020

Accepted

September 22, 2020

Available Online

December 31, 2020


Corresponding author email:

dilawar_qau@yahoo.com

How to Cite

Khan M, Din M, Naeem Z, Sajid Z, Khan D, Amjad MD, Zeb A, Anwar F, Akhtar M, Noreen S. Insights into Acute Myeloid Leukemia: Critical Analysis on its Wide Aspects. Abasyn Journal of Life Sciences 2020; 3(2): 1-9.

Abasyn Journal of Life Sciences , ISSN (online): 2663-1040, Published by Abasyn University