A J Life Sci. 2019, 2 (1): 1-15

Valuing Best Poloxamer Carrier for Meloxicam Solid Dispersions by novel microwave fusion: Designing and Characterization

Keerthi S1, Rajeshpawan A1 Hindustan Abdul Ahad2,* Naveena C1 Yuvasree S1 Venkataramana V1 Raghu U1

1Jawaharlal Nehru Technological University-OTPRI, Ananthapuramu 515001, AP, India.

2Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research(RIPER)-Autonomous, K.R.Palli Cross, Ananthapuramu 515721, AP, India.



Abstract

Present research activity is to establish the best Poloxamer carriers for making solid dispersions (SD) with Meloxicam. The main aim of this investigation is to find the best among the better Poloxamer carriers viz., Poloxamer-108, Poloxamer-188, Poloxamer-237, Poloxamer-338 andPoloxamer-407 for making SD by novel microwave fusion technique. Four portions of Meloxicam: Poloxamer in various ratios (1:1, 1:2, 1:4and 1:6) are used for making SD by microwave fusion technique later compressed using 8 station tablet compression machine. The SD andtablet formulations are evaluated for physicochemical characterization.All the prepared batches found to have satisfactory specifications as per pharmacopoeia. The authors concluded that Poloxamer-188 is found to be the best carrier among the Poloxamer carriers used for makingMeloxicam SD.

Keywords:Meloxicam, Poloxamer, microwave, solid dispersions, tablets.

Received

May 1, 2019

Received Revised

July 2, 2019

Accepted

July 3, 2019

Available Online

July 20, 2019


Corresponding author email:

abdulhindustan@gmail.com

How to Cite

Keerthi S, Rajeshpawan A, AhadHA, Naveena C, Yuvasree S, Venkataramana V, Raghu U.Valuing best poloxamer carrier for meloxicam solid dispersions by novel microwave fusion: Designing and Characterization Abasyn Journal of Life Sciences2019; 2(1): 1-15.