Abstract
Present research activity is to establish the best Poloxamer carriers for making solid dispersions (SD) with Meloxicam. The main aim of this investigation is to find the best among the better Poloxamer carriers viz., Poloxamer-108, Poloxamer-188, Poloxamer-237, Poloxamer-338 andPoloxamer-407 for making SD by novel microwave fusion technique. Four portions of Meloxicam: Poloxamer in various ratios (1:1, 1:2, 1:4and 1:6) are used for making SD by microwave fusion technique later compressed using 8 station tablet compression machine. The SD andtablet formulations are evaluated for physicochemical characterization.All the prepared batches found to have satisfactory specifications as per pharmacopoeia. The authors concluded that Poloxamer-188 is found to be the best carrier among the Poloxamer carriers used for makingMeloxicam SD.
Keywords:Meloxicam, Poloxamer, microwave, solid dispersions, tablets.
https://doi.org/10.34091/AJLS.2.1.1
ReceivedMay 1, 2019
Received RevisedJuly 2, 2019
AcceptedJuly 3, 2019
Available OnlineJuly 20, 2019
abdulhindustan@gmail.com
Keerthi S, Rajeshpawan A, AhadHA, Naveena C, Yuvasree S, Venkataramana V, Raghu U.Valuing best poloxamer carrier for meloxicam solid dispersions by novel microwave fusion: Designing and Characterization Abasyn Journal of Life Sciences2019; 2(1): 1-15.