Treatment of Acute Myeloid Leukemia: A Concise Overview

Authors

  • Mudassir Khan National University of Science and Technology (NUST), Isalamabad
  • Zerbab Naeem Department of Healthcare Biotechnology Atta Ur Rahman School of Applied Biosciences (ASAB), National University of Science and Technology (NUST), Islamabad, Pakistan
  • Kainat Mumtaz Department of Healthcare Biotechnology Atta Ur Rahman School of Applied Biosciences (ASAB), National University of Science and Technology (NUST), Islamabad, Pakistan
  • Zahra Sajid Department of Healthcare Biotechnology Atta Ur Rahman School of Applied Biosciences (ASAB), National University of Science and Technology (NUST), Islamabad, Pakistan
  • Dilawar Khan Department of Healthcare Biotechnology Atta Ur Rahman School of Applied Biosciences (ASAB), National University of Science and Technology (NUST), Islamabad, Pakistan
  • Faizan Ullah
  • Esraa Ghazy Department of Pharmacy, Al-Rasheed University College, Baghdad-Iraq
  • Tahir Omer Department of life sciences and education University of South Wales - Cardiff - United Kingdom

Keywords:

AML, Leukemia, Therapy

Abstract

Acute myeloid leukemia (AML) is a disease characterized by hematopoietic and progenitor stem cells disorder, resulting in their proliferation and accumulation in bone marrow which leads to hematopoietic failure. It is an aggressive form of cancer that typically demands quick decision-making. In case of AML, the addition of drug efflux inhibitors to the chemotherapeutic regimen may improve outcomes in patients. With the advancement in treatment strategies, patients can now receive chemotherapy, radiation therapy or additional stem cell transplants. Specific genetic mutations in leukemic cells provide the direction for treatment and determine the overall survival rate of patients. Older patients have adverse treatment consequences as age is an important factor in AML prognosis. We critically reviewed multiple existing therapies for AML. Optimization of traditional therapies remain major concern of scientists. However, little bit advancement has been made in current years. There is immense need of novel and targeted therapies to treat AML and reduce its relapse chances.

Published

2020-12-31

How to Cite

Mudassir Khan, Zerbab Naeem, Kainat Mumtaz, Zahra Sajid, Dilawar Khan, Faizan Ullah, Esraa Ghazy, & Tahir Omer. (2020). Treatment of Acute Myeloid Leukemia: A Concise Overview . Abasyn Journal of Life Sciences, 3(Issue 2). Retrieved from https://ajlifesciences.com/ojs/index.php/ajls/article/view/80

Issue

Section

Full Length Review